Fri Jan 09 2026

113 articles - From Friday Jan 02 2026 to Friday Jan 09 2026

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Clin Gastroenterol Hepatol
AGA Clinical Practice Update on Evaluation and Management of Refractory Constipation: Expert Review.

These Best Practice Advice statements were drawn from a review of the published literature and from expert opinion. Because systematic reviews were not performed, these Best Practice Advice statements do not carry formal ratings of the quality of evidence or strength of the presented considerations.

Pubmed   Journal   ReadQx 

Gastrointest Endosc
ASGE consensus recommendations on the endoscopic management of eosinophilic esophagitis - part 2: disease assessment, monitoring, and pediatric considerations.

Statements across al age ranges addressed the role of less-invasive monitoring, performing diagnostic endoscopy off treatment, the need to consider symptoms, endoscopic features, and histologic findings when assessing disease activity, treatment-based monitoring intervals, and the approach to esophageal biopsies during monitoring. Coupled with the original consensus work, we provide a comprehensive endoscopic approach to EoE as well as practical guidance for procedure-related aspects in the field to facilitate high-quality endoscopic care to patients with EoE.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther
Meta-Analysis: Prevalence of Eating Disorders in Inflammatory Bowel Disease.

Eating disorders are prevalent among individuals with IBD, particularly avoidant/restrictive types. These findings highlight the need for improved screening and greater clinical awareness to better detect and manage disordered eating in the IBD population.

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Am J Gastroenterol
Comparison of Image-Enhanced Endoscopy Techniques for Colorectal Lesion Detection and Characterization: A Network Meta-Analysis of Randomized Controlled Trials.

Our findings indicate TXI and LCI may provide improved detection performance compared with conventional imaging. Blue light imaging and new-generation NBI seem to enhance lesion characterization. Further comparative studies are needed to guide optimal IEE modality selection for colorectal neoplasia.

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Gastrointest Endosc
Endoscopic techniques for the identification of duodenal villous atrophy in celiac disease: a systematic review and meta-analysis of diagnostic accuracy.

Compared to white-light endoscopy, advanced techniques such as water immersion, narrow band imaging and dye-based chromoendoscopy offer improved sensitivity, particularly for subtle, patchy lesions.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther
Amino Acid Imbalance Is an Independent Factor for Mortality in Patients With Liver Cirrhosis.

Amino acid imbalance is an independent factor for poor prognosis in patients with cirrhosis. Notably, decreased BCAA and increased tyrosine levels were identified as independent prognostic factors.

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Blood Eosinophils Are Accurate Biomarkers for the Management of Eosinophilic Oesophagitis: Prospective, Multi-Centre Study.

Eosinophil absolute and relative counts in the peripheral blood could be used in the initial assessment of patients presenting with dysphagia to accurately differentiate EoE from NED and to predict histological remission of EoE.

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Clinical Trial: Long Versus Short Tapering of Steroids in Steroid Responsive Moderate to Severely Active Ulcerative Colitis-A Randomised Controlled Trial.

A shorter taper duration of 6 weeks was inferior to a longer taper of 10 weeks in achieving clinical remission of UC at 6 months.

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Impact of Evolving Evidence on Pharmacological Therapy for Alcohol-Associated Hepatitis in Alberta: A Population-Based Study of Practice Trends and MELD-Stratified Effectiveness of Corticosteroids.

RCT evidence led to a rapid reversal in PTX prescribing prior to formal guideline updates. Real-world data support a modest short-term benefit of CS and illustrate the potential of target trial emulation to assess treatment effectiveness in specific groups of patients.

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Research Communication: Healthcare Utilisation Patterns in Patients With Irritable Bowel Syndrome Across an Integrated Healthcare System.

All IBS medications were associated with reduced outpatient visits. Our findings enable healthcare systems to better target interventions to reduce unnecessary utilisation and associated costs.

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Research Communication: The Risk and Outcomes of Gastrointestinal Bleeding in Patients Using Warfarin or Direct Oral Anticoagulants.

Patients taking either DOACs or warfarin had more severe GIB and greater mortality than non-anticoagulated patients, even after controlling for comorbid status. Anticoagulated patients also had higher rates of delayed endoscopy.

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Am J Gastroenterol
A Large Language Model Assistant for Summarizing Hepatology Referral Documents.

The use of an LLM led to significantly reduced document length, maintained an appropriate level of accuracy, and led to a significant decrease in clinician time to review the patient record. Future steps involve creating a fully automated workflow that is integrated into the electronic health record for widespread use.

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Adenomatous Polyposis Coli Gene Polyposis-related Syndromes.

In this narrative review, we discuss the epidemiology, diagnosis, and management of APC gene related polyposis syndromes. We also review the variation in genotype-phenotype presentations and discuss practical aspects of caring for individuals affected by these syndromes with an emphasis on multidisciplinary care, family planning, and transitions of care.

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Associations Between Mean Arterial Pressure Thresholds and Clinical Outcomes in Decompensated Cirrhosis With Septic Shock.

Maintaining MAP between 70 and 75 mm Hg may optimize survival and kidney recovery in patients with decompensated cirrhosis and septic shock. Randomized trials are needed to compare traditional MAP targets (60-65 mm Hg) with intermediate targets (70-75 mm Hg) to improve outcomes in this high-risk population.

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Clinical Trial Endpoints for Perianal Fistulizing Crohn's Disease.

Based on our evaluation, future trials should use co-primary clinical and radiologic assessments to capture both how the patient feels and an objective measure of disease activity. These findings reinforce the need for clearly defined, objective, and standardized endpoints for pCD clinical trials that will enable evaluation of novel therapies to improve patient outcomes.

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Psychological Resilience and Mental Wellbeing Mitigate the Risk of Irritable Bowel Syndrome.

Our study demonstrates that enhanced mental wellbeing confers substantial protection against IBS development, highlighting psychological interventions as potential primary prevention strategies.

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The Enterolimbic axis: gut-brain affective circuits at the crossroad of metabolism, emotion, and behavior.

We propose that gastroenterologists embrace these agents as first-line therapies, leveraging the unique endocrine role of the gut in metabolic regulation. This review integrates molecular, clinical, and therapeutic insights to outline diagnostic and precision-medicine opportunities arising from enterolimbic modulation.

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The Utility of MUC2 and CDX2 Expression in the Diagnosis of Barrett's Esophagus: A Community-based Study of Wide-Area Transepithelial Sampling and Forceps Biopsies.

FB misses approximately half of BE when using MUC2/WATS3D as an alternative gold standard. The addition of MUC2 immunohistochemistry may aid in the recognition of BE.

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Clin Gastroenterol Hepatol
Large-scale clustering of longitudinal fecal calprotectin and C-reactive protein profiles in inflammatory bowel disease.

Distinct patterns of inflammatory behavior over time are evident in IBD patients. These data pave the way for a deeper understanding of disease heterogeneity in IBD.

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Real-world effectiveness of advanced therapies in microscopic colitis.

This real-world study demonstrates the promising short- and long-term effectiveness of advanced therapies-particularly JAK inhibitors-in budesonide-refractory and budesonide-dependent MC. These findings pave the way for dedicated prospective trials and highlight evolving therapeutic strategies in MC.

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Week 12 Reduction in MM-SES-CD is Predictive of Delayed Response to Upadacitinib in Crohn's disease.

Delayed clinical response to upadacitinib occurs in a substantial proportion of initial non-responders. Failure to achieve week 12 reduction in MM-SES-CD is associated with high likelihood of delayed non-response, supporting its utility in guiding treatment decisions.

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Endoscopy
Development and Validation of a Multimodal Deep Learning Model for Early Esophageal Squamous Neoplasia Detection and Invasion Depth Prediction.

MUMA-EDx demonstrably delivers exceptional early ESCC detection and robust invasion depth classification, achieving performance comparable to expert endoscopists and poised to significantly enhance diagnostic precision and patient outcomes.

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Multicenter, double-blind, sham endoscopy-controlled, randomized trial evaluating the efficacy of anti-reflux mucosal ablation for the treatment of gastro-esophageal reflux disease.

ARMA was not superior to sham endoscopy in improving GERD-related quality of life at 12 months in patients with PPI-responsive GERD and was associated with a higher incidence of adverse events. These findings do not support its implementation in routine clinical practice. ClinicalTrials.gov registration number NCT04711655.

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Vessel Coagulation in Third Space Endoscopy: a Randomized Controlled Trial.

A substantial reduction in the risk of intraprocedural bleeding was achieved by saline-immersion pre-sealing in per-patient and per-vessel analyses, prompting its implementation in clinical practice.

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Gastrointest Endosc
EFFECTS OF DIFFERENT TECHNIQUES OF ENDOSCOPIC GASTROPLASTY ON WEIGHT LOSS AMONG PATIENTS WITH OBESITY: A RANDOMIZED, SINGLE-CENTER PRAGMATIC TRIAL.

This study underscores the potential of EG through ESG, EVG, and POSE-2 as equally effective, safe, and feasible interventions for managing obesity at a medium-term follow-up. Results were consistent despite incomplete follow-up, the main study limitation, assuming data were missing at random.

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Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Neoplasms: A Multicenter North American Experience.

ESD is a safe and effective treatment for superficial ESN with a low recurrence rate in lesions that meet the standard criteria for curative resection.

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REACT Multipoint Elastic Traction for Colorectal ESD: A Retrospective Single-Center Feasibility Series of 59 Consecutive Cases.

REACT-assisted ESD was safe and feasible in this single-center retrospective analysis of a prospectively maintained consecutive colorectal ESD cohort. Prospective, multicenter studies are warranted to validate these findings and to define the optimal context for this novel traction method.

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Stenosis Development After Circumferential Colorectal Endoscopic Submucosal Dissection: A Multicenter Analysis of Predictive Factors and Outcomes.

The risk of stenosis after circumferential ESD for colorectal lesions ≥90% is high in the rectum but can be effectively managed endoscopically. Despite this, the technique remains highly feasible and safe.

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Gut
<i>Streptococcus anginosus</i>-derived methionine promotes gastric cancer progression.

Background and host.

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CD48 is a novel immune checkpoint on tumour-associated macrophages in hepatocellular carcinoma.

CD48 represents a novel immune checkpoint on TAMs critical for HCC progression and immunotherapy resistance. Targeting CD48 may overcome immunosuppression and increase therapeutic efficacy in HCC.

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Distinct microbial mediators link diet to inflammation in Crohn's disease and ulcerative colitis.

Diet quality influences inflammation in IBD through distinct microbiome pathways specific taxa and metabolites mediate effects in CD, whereas microbial richness and global composition drive protection in UC.

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GSK3β<sup>high</sup>/NFATc1<sup>high</sup> subtype targeting overcomes therapy resistance in pancreatic cancer through transcriptional induction of homologous recombination repair.

We have identified a highly aggressive GSK3β high /NFATc1 high subtype that predicts early recurrence, poor survival and cisplatin resistance in PDAC. This subtype reveals new treatment vulnerabilities suggesting that patients with PDAC may benefit from stratification-based tailored treatment strategies.

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Integrated screens reveal that guanine nucleotide depletion, which is irreversible via targeting IMPDH2, inhibits pancreatic cancer and potentiates KRAS inhibition.

These findings provide a rationale for developing combination therapies targeting KRAS and DNGB, highlighting the potential of purine nucleotide imbalance as a biomarker to guide the application of these therapies.

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Novel <i>myo</i>-inositol to butyrate fermentation pathway in the prevalent human gut species <i>Dysosmobacter welbionis,</i> a bacterium associated with improved metabolic and liver health.

Background -inositol into butyrate, distinguishing it from other commensals and supporting its potential as a next-generation probiotic for metabolic and liver health.

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Pueraria lobata-derived exosome-like nanovesicles alleviate rheumatoid arthritis via targeting <i>Ruminococcus gnavus</i> phenylethylamine production.

Small RNA sequencing and lipidomic analysis were performed to identify key components and reveal the related mechanisms mediating therapeutic effects. Results in aggravating RA and underscore the application of plant-derived ELNs for microbiota manipulation.

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Simvastatin in the prevention of recurrent pancreatitis: a triple-blinded randomised clinical trial (the SIMBA trial).

This trial, evaluating simvastatin versus placebo for the prevention of pancreatitis, did not demonstrate a reduction in recurrence rate, although results might be underpowered due to early termination. The relationship between statins in these patients and new-onset diabetes requires further investigation.

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Targeting MLCK1 uncouples immune checkpoint inhibitor-induced colitis from antitumour immunity.

These findings suggest that MLCK1-dependent tight junction regulation is essential for ICIs colitis, positioning barrier restoration as a potential therapeutic strategy.

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J Hepatol
Molecular profiling and matched targeted treatment in cholangiocarcinoma: results from the Italian dataset (ANITA).

Despite a broader availability of EMP in advanced CCA, patient access to targeted treatments remains suboptimal. Our results demonstrate that such treatments can dramatically impact on OS, Therefore, strategies aiming at increasing the access to (and accelerate the availability of) targeted treatments are warranted. Clinical trial number ESR-21-21387.

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J Neurogastroenterol Motil
Changes in Esophageal Transit Scintigraphy After Peroral Endoscopic Myotomy in Patients With Achalasia.

Patients with achalasia who received POEM showed improved not only manometric LES parameters but also esophageal transit. Analysis of the radiation curve's time-to-peak showed that improved retention in the upper portion is an indicator of symptoms improvement in patients who underwent POEM.

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Loss of Inspiratory Augmentation as a Predictive Factor for the Development of Gastroesophageal Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia.

Loss of inspiratory augmentation may predict GERD after POEM.

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Mean Basal Esophagogastric Junction Pressure Is a Better High-resolution Manometry Predictor of Gastroesophageal Reflux Disease Than Esophagogastric Junction Contractile Integral.

MBEP is a simple HRM metric to evaluate anti-reflux barrier function, predicting conclusive GERD and differentiating reflux phenotypes with better performance than EGJ-CI. This metric could serve as a valuable adjunctive tool in GERD diagnosis.

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Pylorus Endoluminal Functional Luminal Imaging Probe Measurements in Children Are Determined by Age and Are Distinctly Different From Adult Values.

Pediatric pylorus EndoFLIP values are determined by age but not weight and they correlate with symptoms of impaired gastric emptying. Adults normal values are not applicable to children. There is a need to set up a separate pediatric protocol for pylorus EndoFLIP.

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Spatiotemporal Remodeling of Enteric Neural Pathways Underlies Colonic Dysmotility Following Spinal Cord Injury in Rats.

SCI induces spatiotemporal remodeling of excitatory and inhibitory neural pathways, contributing to colonic dysmotility and revealing potential targets for therapeutic intervention.

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Transient Gastric Pressure Elevation Synergizing With Impaired Esophagogastric Junction Barrier Function Plays a Pivotal Role in the Refractory Gastroesophageal Reflux Disease.

Transient gastric pressure elevation and compromised EGJ barrier function drive weakly acidic reflux and esophageal bolus exposure. This pressure gradient-barrier mismatch underpins the refractoriness of RGERD.

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Validation of the Leuven Postprandial Distress Scale According to the Rome IV Criteria for Functional Dyspepsia.

The LPDS questionnaire showed good reliability and responsiveness, and can be confidently used as a validated tool in Rome IV PDS populations. Data did not support adding accessory symptoms to the construct, due to low loading or poor model fit.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther
Editorial: Decoding Gut Failure in Cirrhosis: Villin-1 and the Emergence of a Seventh Organ Failure.

Pubmed   Journal   ReadQx 

Editorial: Dysfunctional Neutrophils in Cirrhosis With Acute Decompensation: Why It Matters.

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Clin Gastroenterol Hepatol
Is it Time to Treat to Histologic Remission Yet?

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Gastroenterology
Emerging Diagnostic Indications for Endoscopic Ultrasound.

Finally, EUS-obtained tissue now seeds organoids, patient-derived xenografts, and organotypic slice cultures to test individualized therapies. Collectively, these innovations move EUS beyond "see and biopsy" toward detect, predict, and personalize.

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Gut
Combination therapies for metabolic dysfunction-associated steatohepatitis: challenges and opportunities.

This review integrates current knowledge on multitargeted and combination therapies for MASH, examines mechanistic rationales and emerging clinical evidence and addresses practical considerations for patient-centred implementation. Therefore, we aim to provide clinicians and researchers with a comprehensive framework to optimise individualised management and improve both hepatic and systemic outcomes in individuals living with MASH.

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Road to IBD prevention in the Global South: a conceptual framework modelling from non-communicable diseases.

Therefore, in this review, we advocate for an alternative approach of combining evidence-based IBD prevention strategies with the time-tested strategies of NCD prevention approaches already being implemented. We suggest a sieving strategy for selecting preventive measures through a series of sieves-interventions that have evidence to support prevention, align with NCD prevention and are economically viable.

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J Neurogastroenterol Motil
Expanding the Physiological Role of the Endoluminal Functional Lumen Imaging Probe From the Esophagus to Pediatric Pylorus.

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Is Mean Basal Esophagogastric Junction Pressure a Simpler and More Reliable Marker for Gastroesophageal Reflux Disease Barrier Function?

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Neural Gastric Electrical Stimulation: Future Prospects in Managing Gastric Emptying Disorders.

This review examines the evolution and implementation of NGES, focusing on its potential role as a treatment option to enhance gastric propulsion in gastroparesis and delayed gastric conduit emptying. While initial acute animal studies have shown promising results, continued development of the technology and refinement of stimulation protocols through chronic experiments remains essential for successful clinical translation.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol
ACG 2025 Presidential Speech.

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Calendar of Courses, Symposiums and Conferences.

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How I Approach It: A Roadmap for AI in GI Fellowship Training.

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Inverted Hyperplastic Polyp of the Duodenum.

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Navigating Complexities in the Liver ICU: A Fireside Chat with a Liver Intensivist.

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Response to Shah et al and Li et al.

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Something fishy in the liver - an unexpected mass in a patient with heavy alcohol use.

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The appendix as a diagnostic blind spot: a case of concealed tubular adenoma.

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Endosc Int Open
Search, coagulation, and clipping with the shrink method to minimize ulcer base and prevent delayed bleeding after gastric endoscopic resection.

Pubmed   Journal   ReadQx   PMC

Endoscopy
"Umbrella-shaped pulley traction" assisted endoscopic submucosal dissection of colonic lesions - a modified external traction technique.

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A fishy situation - expanding the differential diagnosis of the fish-mouth papilla.

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A helix tacking system for the management of colonic anastomotic dehiscence, after a laparoscopic left colectomy.

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A novel approach: a pancreatic duct stent removable with the nasobiliary catheter.

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Cholangioscopy and double guidewires facilitate a difficult endoscopic ultrasound-guided gastroenterostomy.

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Combined digestive endoscopy and laryngoscopy for successful management of an early-stage epiglottic carcinoma.

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Endoscopic stricturoplasty for pyloric stenosis refractory to endoscopic balloon dilation and lumen apposing metal stenting.

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Endoscopic synchronous injection and submucosal dissection for large granular mixed nodular laterally spreading tumor in the rectum.

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Endoscopic ultrasound-guided antegrade transpapillary multi-hole self-expandable metal stent with fine-gauge stent delivery system.

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Endoscopic ultrasound-guided choledochoduodenostomy as a life-saving salvage therapy for post-transplant acute biliary obstruction.

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High-fidelity endoscopic submucosal dissection simulator reproducing full-procedure training, bleeding, and perforation.

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Knocking stent release technique to deploy lumen-apposing metal stents during endoscopic ultrasound-guided gallbladder drainage.

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Next step for antireflux mucosal ablation.

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Rescue surgery for intra-abdominal migration of plastic stents in endoscopic ultrasound-guided hepaticogastrostomy.

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Side-by-side 6-mm multi-hole metal stents more effective than inside plastic stents for reintervention after stent-in-stent placement in malignant hilar biliary obstruction.

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Successful endoscopic submucosal dissection of a large laterally spreading tumor in distal jejunum by the water pressure method using a newly developed double-balloon enteroscope.

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Tetra-side-by-side technique using a multi-hole self-expandable metal stent with a 5.9-Fr stent delivery system.

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Transcolonic endoscopic appendectomy using a novel integrated snare-knife device: a case report.

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Underwater internal traction-assisted reopenable clip-over-the-line method for full-thickness defect closure in a gastric collapse.

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Gastroenterology
Altered Metabolites at Birth in Individuals With Later Inflammatory Bowel Disease: A Danish Cohort Study.

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Life-Threatening Hematemesis and Esophageal Stricture in a 9-Year-Old Boy: Unmasking the Culprit.

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The Human Blood Virome Differs in Crohn's Disease.

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Unexplained Coexisting Injury of the Liver, Pancreas, and Brain.

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Gastrointest Endosc
Technical Refinement in transjugular intrahepatic portosystemic shunt for Cavernous Transformation of the Portal Vein: Role of EUS-Guided Navigation (with video).

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Gut
Commentary on: gutjnl-2025-335548.R2-endoscopic retrograde cholangiopancreatography (ERCP) services across the UK.

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Feasibility of endoscopic submucosal dissection for large (≥3 cm) laterally spreading duodenal tumours involving the papilla: a multicentre retrospective study.

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PEG is back: revisiting the role of pegylated interferon alfa and benchmarking its place in HBV cure strategies.

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Recovery of HBV-specific B cell function after discontinuation of nucleos(t)ide analogue therapy: new insight and future challenges.

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Refining watch-and-wait in low rectal cancer after neoadjuvant chemoradiotherapy: pilot study of endoscopic full-thickness resection.

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When the vascular lining loosens, dysfunctional macrophages permit pathological bacterial translocation in cirrhosis.

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Hepatology
Letter to the Editor: Clarifying validation and statistical aspects of AI-Based risk prediction in liver disease.

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Letter to the editor: Interpreting the clinical decision value of glycomic-based models for early HCC detection in CHB.

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Protecting the future generation through science and HBV vaccination.

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Response to "clarifying validation and statistical aspects of AI‑based risk prediction in liver disease".

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J Neurogastroenterol Motil
Corrigendum: Implementing a Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet in Asia: Addressing Cultural, Clinical and Practical Challenges.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther
Editorial: Decoding Gut Failure in Cirrhosis-Villin-1 and the Emergence of a Seventh Organ Failure. Authors' Reply.

Pubmed   Journal   ReadQx 

Editorial: Dysfunctional Neutrophils in Cirrhosis With Acute Decompensation-Why It Matters. Authors' Reply.

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Letter: Association Between Viral Replication Activity and Post-Transplant Recurrence of HBV-Related Hepatocellular Carcinoma.

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Gastroenterology
Comment on "Cost-effectiveness of regular surveillance versus endoscopy at need for patients with Barrett's esophagus: economic evaluation alongside the BOSS randomized controlled trial".

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Limitations and Implications for Barrett's Esophagus Surveillance.

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Revising the Model for Accurate Cost-Effectiveness of Barrett's Esophagus Surveillance.

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Gastrointest Endosc
Navigating the gray zone: refining risk stratification after endoscopic resection for cervical esophageal squamous cell carcinoma.

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Gut
Mutations of Gly277 in <i>CPA1</i>-related chronic pancreatitis: clinical clues for misfolding aetiology.

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My first 1000 manuscript rejections.

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Proton pump inhibitors use and risk of inflammatory bowel disease in children.

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Role of A2 beta casein in milk-induced eosinophilic oesophagitis: novel in-vivo and in-vitro findings.

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J Neurogastroenterol Motil
Interstitial Cells of Cajal Remodeling as a Mechanistic Insight Into the Natural History of Achalasia: Lessons From 3 Clinical Cases.

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Mast Cell Activation Affecting Gastrointestinal Motility.

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Mean Nocturnal Baseline Impedance in Gastroesophageal Reflux Disease: Considerations on the Study by Lee et al.

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Reply: Mean Nocturnal Baseline Impedance in Gastroesophageal Reflux Disease: Considerations on the Study by Lee et al.

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